MATERIALS AND METHODSThis prospective randomized controlled clinical trial was conducted from September 2012 to October 2013 and included patients who underwent microincision cataract surgery (MICS) at Virgen de los Lirios Hospital. The study enrolled 60 eyes of 41 patients. Eligible patients were those aged 65 to 80 years with senile cataract and no other concomitant disease that would preclude a postoperative best-corrected visual acuity (BCVA) of 20/40 or better. Exclusion criteria included history of ocular surgery or trauma, corneal disease, glaucoma, uveitis, vitreous opacities, retinopathy, or visual pathway abnormalities. Other exclusion criteria were current treatment with systemic steroids, immunosuppressants, anticoagulants, or prostaglandin analog eye drops. Patients with intraoperative complications or prolonged surgical duration were also excluded. After obtaining informed consent, participants with a history of penicillin allergy were assigned to the vancomycin group (group 1). An equal number of patients were randomly selected and assigned to the control group (group 2). Information collected from patients included date of birth, gender, history of drug allergy and systemic diseases, medication use, and surgeon. Patients in group 1 received an intracameral injection of vancomycin (1 mg in 0.1 ml), while those in group 2 received an intracameral injection of cefuroxime (1 mg in 0.1 ml). Vancomycin injection was prepared from 500 mg of commercially available vancomycin hydrochloride powder (Combino Pharm SL, Barcelona, Spain) and diluted with balanced salt solution (BSS®, Alcon Cusí, Barcelona, Spain) to obtain a 1 mg/0.1 ml solution. Similarly, cefuroxime injection was prepared from 750 mg of cefuroxime powder (Laboratorios Ramón Sala...... middle of paper ......r no flare, grade 1 for barely detectable , grade 2 for an obvious flare with iris details clearly visible, grade 3 for marked flaring and iris details not clearly visible, grade 4 for the presence of aqueous plastic and fibrin in the iris. anterior chamber. Statistical analysis Data were coded and analyzed using the statistical software package SPSS Statistics (version 21.0, SPSS Inc, Chicago, USA) between groups for baseline demographic and clinical characteristics. UCVA, refraction, BCVA, corneal pachymetry, IOP and endothelial cell count between preoperative and postoperative examinations were calculated using a paired t test. Comparisons between. groups were performed using an unpaired t test for continuous. variables and Mann-Whitney U test for ordinal variables A value of P.

Essay / MATERIALS AND METHODSThis prospective randomized controlled clinical trial was conducted from September 2012 to October 2013 and included patients who underwent microincision cataract surgery (MICS) at Virgen de los Lirios Hospital. The study enrolled 60 eyes of 41 patients. Eligible patients were those aged 65 to 80 years with senile cataract and no other concomitant disease that would preclude a postoperative best-corrected visual acuity (BCVA) of 20/40 or better. Exclusion criteria included history of ocular surgery or trauma, corneal disease, glaucoma, uveitis, vitreous opacities, retinopathy, or visual pathway abnormalities. Other exclusion criteria were current treatment with systemic steroids, immunosuppressants, anticoagulants, or prostaglandin analog eye drops. Patients with intraoperative complications or prolonged surgical duration were also excluded. After obtaining informed consent, participants with a history of penicillin allergy were assigned to the vancomycin group (group 1). An equal number of patients were randomly selected and assigned to the control group (group 2). Information collected from patients included date of birth, gender, history of drug allergy and systemic diseases, medication use, and surgeon. Patients in group 1 received an intracameral injection of vancomycin (1 mg in 0.1 ml), while those in group 2 received an intracameral injection of cefuroxime (1 mg in 0.1 ml). Vancomycin injection was prepared from 500 mg of commercially available vancomycin hydrochloride powder (Combino Pharm SL, Barcelona, Spain) and diluted with balanced salt solution (BSS®, Alcon Cusí, Barcelona, Spain) to obtain a 1 mg/0.1 ml solution. Similarly, cefuroxime injection was prepared from 750 mg of cefuroxime powder (Laboratorios Ramón Sala...... middle of paper ......r no flare, grade 1 for barely detectable , grade 2 for an obvious flare with iris details clearly visible, grade 3 for marked flaring and iris details not clearly visible, grade 4 for the presence of aqueous plastic and fibrin in the iris. anterior chamber. Statistical analysis Data were coded and analyzed using the statistical software package SPSS Statistics (version 21.0, SPSS Inc, Chicago, USA) between groups for baseline demographic and clinical characteristics. UCVA, refraction, BCVA, corneal pachymetry, IOP and endothelial cell count between preoperative and postoperative examinations were calculated using a paired t test. Comparisons between. groups were performed using an unpaired t test for continuous. variables and Mann-Whitney U test for ordinal variables A value of P.

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