The presence of pesticides in fruits, vegetables, cereals, in other food products and even in breast milk is a matter of serious concern (Munshi et al. 2001; FAO/WHO 2005; Damgaard et al. There are many other studies that describe the presence of pesticides as residues in foods above established maximum residue limits (MRLs) (Bajpai et al. 2007; Devanathan et al. al. 2009; Srivastava et al. 2011). 4,700 samples of peppers, cauliflower, wheat grains and melons were analyzed (European Commission 2001). Methamidophos residues exceeded MRLs most often in all vegetables (8.7%), followed by the maneb group (). 1.1%), thiabendazole (0.57%), acephate (0.41%) and benomyl group (0.35%). In Brazil, more than 90% of compound milk samples contained organochlorine pesticide residues. Of 100 composite samples, 44% contained aldrin followed by DDT (36%), mirex (34%), endosulfan (32%), chlordane (17%), dicofol (14%) and heptachlor (11%). and dieldrin (11%) (Avancini et al. 2012). About 20% of Indian food products were contaminated with pesticide residues above the tolerance level, compared to only 2% globally (TERI 2000). health chances. Although pesticides have been formulated to kill targeted pests, they have also been shown to be toxic to non-target species and humans are no exception. Many accidents have been reported in different parts of the paper world......cide. In this mode of action, pesticides structurally similar to the cognate ligand bind to the active NR, causing conformational changes leading to the release of inappropriate signals (Ruegg et al. 2009). The indirect mechanism of endocrine disruption may be due to inhibition of steroidogenic enzymes and binding to steroid transport proteins (Tebourbi et al. 2011). In this mode of action, pesticides compete for common cofactors and indirectly disrupt the nuclear activity of NRs. Other possible mechanisms of indirect endocrine disruption include xenosensor-induced receptor ubiquitination followed by targeted degradation of the NR in the proteosome; transcription of enzymes involved in hormonal metabolism induced by xenosensors; block gene regulation via nuclear receptor elements by binding xenohormones to inhibitory xenobiotic response elements (Ruegg et al.. 2009).