Staphylococci, enterococci and streptococci are considered one of the main causes of many diseases. They are considered different because of their body shape. Staphylococci and Streptococci acquire a round, spherical cell shape. On the other hand, the arrangement of cells is considered different for the two organisms. For example, Staphylococcus aureus is a cluster-forming, Gram-positive cocci and non-sporulating facultative anaerobe found in grape-like structures. Enterococci are also short-chain Gram-positive cocci and are considered facultative anaerobes. They can grow in a temperature range of 10 to 45 degrees Celsius. Enterococcus is recognized as the main cause of nosocomial infections. The golden yellow colonies indicate that S. Aureus can ferment mannitol while Enterococcus and Streptococcus are unable to ferment mannitol. Additionally, S. aureus is coagulase positive and has the ability to coagulate plasma, making it unique from other organisms. About 30% of humans carry S. aureus in the nose, back of the throat, or on the skin. The catalase test is also considered one of the main differences because streptococcus is catalase positive while staphylococcus is catalase positive. Catalase is an enzyme capable of destroying the dangerous chemical called hydrogen peroxide. Staphylococcus aureus is found in the normal human flora. It is normally found in the nose and on the skin. It is known as one of the five most common causes of infections after injury or surgery. It is transmitted by air droplets. For example, when an infected person coughs or sneezes, they tend to release small droplets of saliva into the air. The droplets contain bacteria and can infect the middle of paper... puncture trauma, but may also be linked to the increased use of intravenous drips and catheters, considered compromising devices. It is also responsible for urinary tract infections, bacteremia, endocarditis, meningitis and can be found in wound infections alongside many other bacteria. Although there are more than 15 species in this genus, 80-90% of clinical isolates are Enterococcus faecalis. E. faecalis is known as the most antibiotic-resistant bacteria, making it the most pathogenic among other organisms. It contains many natural resistances to antibiotics, as well as several acquired immunities transferred into R plasmids. Early detection is important, especially if an infection is restricted to a hospital setting. Vancomycin is the most effective antimicrobial agent for preventing E. faecalis infections, although resistance to this agent is increasingly common..