Throughout the play, Macbeth has gone mad because he is killing all these people. First, he goes crazy because he kills King Duncan. After that he goes crazy because he kills Banquo, his madness was shown by seeing Banquo's ghost at the dinner. Lady Macbeth also has her share of madness when she says that as often as she washes her hands, she will never be able to get rid of the blood that is spilled on them. To restate the theme of the second scene of act four, Lady Macduff says: “He had none; his flight was madness. When our actions fail to do so, our fears make us traitors” (lines 2-4). She thinks her husband is crazy for leaving his family there unprotected, which ties into the theme of