The famous "cancer drug penicillin" is probably an apt nickname for cisplatin due to its widespread use worldwide as the first and one of the most effective treatments for many cancer diagnoses. An important thing to emphasize is that cisplatin is a very simple inorganic molecule compared to other anticancer drugs which are generally complex organic molecules. In order to design and develop new anticancer drugs, cisplatin has been used as a golden model by many scientists. General Information Cisplatin is a metal-based cancer chemotherapy drug that comes in the form of a clear liquid and can be administered directly into a vein by injection. It can target rapidly growing cancer cells to slow or stop the proliferation of cancer cells and ultimately cause apoptosis. The systematic name of cisplatin is cis-diamminedichloroplatinum(II) and CDDP is the abbreviation. The trade name of cisplatin on the market is Platinol® (cisplatin for injection) or Platinol®-AQ. History The reason why cisplatin is called the "cancer penicillin" is because of its widespread use and it was also the first large and strong chemotherapy drug in drug history. It was first synthesized in 1845 by Michel Peyrone and also known as Peyrone chloride. At the time cisplatin was discovered, no one actually thought it could be used against cancer, and it was just one of the inorganic compounds that researchers used to prove that one of their synthetic pathways could work. About 50 years later, this became an important factor in the establishment of the theory of coordination chemistry by Alfred Werne, in work where he discovered the precise square planar configuration of cisplatin and pointed out the difference between cis and the trans..... . middle of article ......d with surgery or radiotherapy for different types of cancers.ConclusionSince the discovery of cisplatin, thousands of platinum complexes have been evaluated, but only five have been approved. Therefore, more than 10,000 compounds need to be screened to obtain a new anticancer drug that is more effective than cisplatin using inorganic or coordination chemistry. The solubility, reactivity, electronic and steric effects and configuration of metal complexes can be controlled by changing the metal to another transition metal such as Pd and Ni or the ligand around the metal atom. It has been reported that both metal and ligand can determine biological activity. Hopefully we can find more effective drugs that might contain far fewer side effects than cisplatin, as well as solve the problem of overcoming drug resistance of some cancers to cisplatin..