STUDIES RELATED TO CLINICAL ASPECTS OF MALARIAMalaria is a complex disease with different manifestations in different parts of the world depending on a few variables (Bin Mohanna et al. 2007). Anemia and splenomegaly were found to be significantly associated with malaria among asymptomatic schoolchildren in Hajr Valley, Hadramout (Bin Mohanna et al. 2007). Agina and Abd-Allah (1999) conducted a case-control study on the association of nitric oxide levels with the severity and outcomes of cerebral malaria in Yemeni hospitalized patients. The main clinical manifestations in patients with cerebral malaria were fever (76.4%), pallor (72.0%), hypoglycemia (67.4%), splenomegaly (60.5%), deep coma (39.5%), jaundice (18.6%), pulmonary edema (13.9%). %), subconjunctival hemorrhage (13.9%), severe anemia (53.5%) and hemoglobinuria (6.9%) while in patients with non-cerebral malaria the clinical presentations were fever (83 .8%), pallor (67.7%), splenomegaly (66.0%), jaundice (9.7%), severe anemia (51.6%) and hypoglycemia (3.2%). Serum nitric oxide levels were found to be higher in patients with cerebral malaria than in those without it. In the case of cerebral malaria, nitric oxide levels were very elevated in patients with deeper and longer-lasting coma, as well as in those who died from cerebral malaria, indicating its association with indices of severity and progression of the disease in patients with cerebral malaria (Agina and Abd-Allah). , 1999).Sheiban et al. (1998) studied severe acute renal failure secondary to falciparum malaria in children receiving antimalarial and other supportive treatments and peritoneal dialysis referred to the renal unit of Al-Thawra Hospital in Sana’a. In this study, it was concluded that significant differences were found between children who died (43.8%) and those who survived with respect to age, plasma creatinine, plasma bilirubin, systolic blood pressure and diastolic, hemoglobin concentration, urine output and time since diagnosis. to the reference. However, gender, alanine aminotransferase level, fever grade, plasma sodium or potassium levels were not found to be statistically different between these two groups (Sheiban et al. 1998). The author found that prior immunity, indicated by the presence of splenomegaly, was associated with a better prognosis both in terms of lower mortality and less obvious hemodynamic disturbances in older children due to 'previous exposure to malaria infection, and therefore to the development of immunity (Sheiban et al. It is important to note that malaria is the cause of 5.9% of chronic kidney failure in patients undergoing regular hemodialysis in Hadramout Governorate (Badheeb 1998) Recently, Al Rohani et al (2011) reported that malaria is the most common infectious disease causing acute kidney injury (AKI) in Yemeni patients...