1. IntroductionBotulism or sausage poisoning, name "botulism" similar to "botulus" in Latin meaning sausage, was first recognized in the late 1700s after the disease appeared in southern Germany. Around the 1820s, German neurologist Justinus Kerner studied and explained that the disease was linked to the ingestion of spoiled sausages. Kerner isolated the substance from the sausage and described that the sausage contained a toxic substance that responded to clinical signs related to botulism, but the deadly poison was still unknown. In 1895, it was discovered that the etiological agent incriminated in the alterations was a bacteria which is Clostridium botulinum (C. botulinum) by Emile Van Ermengem and published in 1897 (Julie and Dorothy, 2007). The bacterium Clostridium botulinum is a Gram-positive anaerobic bacillus caused by the action of botulinum neurotoxin (BoNT). Common property of spore production by C. botulinumn which exhibit high resistance to physical and chemical agents. Resistant spores can spread worldwide in the biosphere and spread in soil, dust, water, vapors, fresh and salt water mud as well as wastewater and can ultimately contaminate several foods. Under optimal nutritional and physical conditions for C. botulinum (anaerobiosis, low acidity with pH above 4.5, low salt and sugar concentration, nutrient sufficiency), a vegetative cell form forms and ultimately becomes BoNT from spores. At a temperature of 100°C, these organisms can survive for up to 2 hours. C. botulinum has a very effective neurotoxin, a mouse is killed by as little as 10 picograms of neurotoxin and 1 nanogram per kilogram of body mass is a toxic dose in humans. At a temperature of 85°C, these neurotoxins are heat labile and are quickly inactive...... middle of paper ......imens. One of the treatments is botulism antitoxin, the effects of which are specific to the early stage of the disease. If detected at an advanced stage, this antitoxin does not have good effects on the disease. Nutritional support and rehabilitation to improve neurocognitive function are also used for relief. In some cases, part of the motor paralysis can use guanidine hydrochloride (50 mg/kg) to reverse (Teguh et al., 2007).6. Personal Perspective and Comments Tubolism is an important disease because it is caused by an environment involving water, soil, air, and animal debris contaminated with C. botulinum. This bacteria can generate BoNT to inhibit the release of acetylcholine and cause flaccid paralysis. The best and easiest way to protect the body is to eat cooked food, drink warm water to kill bacteria before consuming it, and wear a bacteria mask when working in a potentially contaminated area..