DISCUSSIONPyogenic infections are characterized by severe local inflammation, usually accompanied by the development of pus. It is an incursion and growth of a pathogenic microorganism in a body part or tissue, which can lead to tissue damage and the development of overt disease through various cellular or cellular mechanisms. toxic, usually caused by one of the pigeon's bacteria. Infectious microorganisms such as Staphylococcus, Streptococcus, Neisseria, Klebsiella, Proteus, Pseudomonas (Sarala et al., 2010), Escherichia coli, Salmonella typhi, Mycobacterium tuberculosis (Singh et al., 2013) and some other species of pathogenic bacteria usually produce pus. . It is usually a source of infection for others and transmission can be due either to direct contact or through fomities. To remedy the problem, antibiotics are the main options. Choosing an effective antimicrobial agent for a microbial infection requires knowledge of the potential microbial pathogen, an understanding of the pathophysiology of the infectious process, and an understanding of the pharmacology and pharmacokinetics of the therapeutic agents being considered (Kelwin, 1999) . aimed to isolate and identify bacteria from clinical pus samples obtained from the patient suspected of pyogenic infection and to detect the drugs of choice against the infection. Furthermore, this study was carried out to determine the socio-economic traits and pyogenic infection-related traits associated with pathogenic infection among patients at a tertiary care center in Salem, Tamil Nadu, India. Goswami et al. (2011) reported that the predominant organisms isolated from wounds were Staphylococcus aureus 48 (26.23%), Klebsiella pneumoniae 38 (20.77%), Pseudomonas aeruginosa...... middle of article.... ..d. In the present study, Klebsiella spp. isolates were resistant to ampicillin, rifampicin, erythromycin and streptomycin, cefotaxime and tetracycline, amikacin, cefuroxime and imipenem. P. aeruginosa isolates from the pyogenic abscess were resistant to all antibiotics tested except imipenem. Protea spp. isolates were resistant to cefotaxime, ampicillin, tetracycline, rifampicin, erythromycin, streptomycin, amikacin, and gentamicin. Isolates of E. coli were resistant to ampicillin, tetracycline, rifampicin, erythromycin and streptomycin, cefotaxime, ceftriaxone and amikacin. The frequency of single and multiple drug resistances is alarmingly high. This could be a reflection of misuse of antimicrobials, lack of diagnostic laboratory services, or unavailability of drug selection guidelines. Thus, a balanced use of medications must be achieved.