How has the DNA technology revolution changed our understanding of medicine and disease?Intro;When Watson and Crick discovered the double helix structure of DNA in 1953, they claimed the discovery was "finding the secret of life." However, as in all scientific activities, the chronicle did not stop there. 60 years later, a team led by chemist “Shankar Balasubramanian” and cancer biologist “Steve Jackson” discovered an unusual arrangement of four-stranded DNA, known as G-quadruplexes that occur in telomeres, those G-quadruplexes that have been shown to have an affinity with genes that play a role in controlling cell proliferation (these could play a role in treating cancers by stopping their proliferation with future research) (http : //www.cam.ac.uk/research/news/a-new-dimension-to-dna-and-personalised-medicine-of-the-future#sthash.Kzyo4IZP.dpuf) Knowledge of the human genome has been exponential Along with growth, knowledge of the “epigenome” has also expanded over the past 10 to 15 years, with the result that we know even less than we imagined. The implications are piling up more and more, and we are compiling more data daily than we know what to do with or how to coherently analyze it. We will have a future of individualized medicine, gene-targeted therapies, capable of turning any gene of interest on or off via DNA hypermethylation, or hypomethylation, histone modification, remodeling RNAi and chromatin; Having the ability to target overexpression, or lack of overexpression, with targeted gene therapies would allow us to treat disease before it even appears. There are trials around the world of newborns having their genome mapped to look for a disease, a single base. change can silence or overexpress the ...... middle of document ......ology for disease control: past, present and future David Weatherall, Brian Greenwood, Heng Leng Chee and Prawase Wasi4. Integrating large-scale genomic information into clinical practice, Steve Olson, Sarah H. Beachy, claire f. Giammaria, and Adam v. Berger, rapporteurs, 2012; iso ; 978-0-309-22034-7)5. http://www.lifetechnologies.com/au/en/home/life-science/sequencing/next-Generation-sequencing/ion-torrent-next-Generation-sequencing-applications.html)6. Science. March 21, 2014; 343 (6177): 1360-3. doi:10.1126/science.1250212. Online publication February 27, 2014. In situ sequencing of highly multiplexed subcellular RNA. Lee JH1, Daugharthy ER, Scheiman J, Kalhor R, Yang JL, Ferrante TC, Terry R, ​​Jeanty SS, Li C, Amamoto R, Peters DT, Turczyk BM, Marblestone AH, Inverso SA, Bernard A, Mali P, Rios X, Aach J, Church GM.7. http://www.wired.com/2014/05/synthetic-dna-cells/?mbid=social_fb