IntroductionPolypharmacy in the elderly is a growing concern in the US healthcare system. Patients who have comorbidities and take multiple medications are at higher risk for potential adverse drug reactions. There is a great need for nursing interventions to perform a patient medication review, also known as a “brown bag.” When nurses obtain patient history data during a provider visit, they should ask "what medications are you taking?" ” and the answer should also include over-the-counter medications. If the response does not include any medications other than prescribed medications, it is the responsibility of nursing professionals to further question the patient to ensure that no over-the-counter medications or supplements are being consumed. This is also an opportunity for the nurse to question any adverse effects that the patient might experience following the medications. Polypharmacy can result from patients having multiple prescribers and pharmacies, and patients continuing to take medications that have been discontinued by the physician. Nurses are in a unique position to provide early detection and intervention for potentially inappropriate medications and associated adverse effects. Project Objective PICO Question: Among older patients receiving care at Cary Medical Center on Med/Surg, who are currently taking multiple medications due to comorbidities, would reviewing medications at each provider visit reduce polypharmacy and its associated adverse effects? Currently, through observations and clinical experience with Med/Surg at Cary Medical Center, medications are administered by the nurse. Nurses are responsible and accountable for administering medications to patients. Bear with me... middle of article... there is a gap in the number of studies conducted on this question. From the studies reviewed, the results demonstrate that the growing health-related problem of polypharmacy among older adults requires immediate attention from healthcare professionals. Studies have found that in conjunction with drug review (brown bag), the STOPP criteria are an effective tool for detecting PIDs. Studies also found that nurses are able to address and assess adverse drug reactions associated with polypharmacy using “brown bag,” medication review, and STOPP criteria. Regarding the PICO question, the results of these studies support the essential need for medication review by nurses and healthcare professionals at each provider visit to reduce the risk of polypharmacy and associated adverse effects..