Howard Robard Hughes (December 24, 1905 – April 5, 1976), pilot, film producer, playboy and one of the richest people in the world during his lifetime, was well known for his eccentricity. His eccentric behavior is believed to be the result of obsessive-compulsive behavior. The purpose of this review is to illustrate Mr. Hughes' anomalies, to arrive at a clinical diagnosis using the five axes of the Diagnostic and Statistical Manual of Mental Disorders IV-TR (DSM-IV-TR), to explain its behavior from a biological theoretical point of view. , and finally to arrive at a hypothetical treatment plan. Behavior: To begin, what constitutes abnormal behavior in Mr. Hughes' case? As early as the 1930s, Hughes showed signs of obsessive-compulsive disorder. Obsessive-compulsive disorder is identified by the DSM as being characterized by recurring obsessions (persistent thoughts, ideas, impulses, or images that seem to take over a person's consciousness) or compulsions (repeated, rigid behaviors or mental acts that people have the feeling of having to accomplish in order to prevent or reduce anxiety) (Cormer, 2008). Close friends reported that Hughes was obsessed with the size of peas, one of his favorite foods, and used a special fork to sort them by size. Those who have interacted with him as a director comment on his obsessions. While making a film, Hughes focused on a minor defect in an actress's top, claiming that the fabric bunched up along a seam and gave the appearance of two nipples on each breast. He was reportedly so upset by the matter that he wrote a detailed memorandum to the crew on how to resolve the problem (Hack, 2002). An executive producer who worked with Hughes wrote in his autobiography about the difficulty of managing middle of paper......he showed that exercise, outdoor activities and socializing lead to increased levels serotonin and overall health (Young, 2007). Although biological treatment through pharmacotherapy, physiotherapy and nutritional therapy will begin to produce the desired results towards a cure, the prognosis for recovery from this disorder would be greatly improved by a combination of behavioral and cognitive measures. , and drug therapies. Patients who receive a combination of these therapies achieve greater relief from their symptoms than single approaches (Kordon et al., 2005). It is unfortunate that Mr. Hughes was unable to receive adequate help for his disorder during his life. Considering the above treatment plan, as well as the benefits of current research and Mr. Hughes' ability to receive the best care, his prognosis at this time would have been quite good..